Rabbit Secondary Antibodies
ABclonal Technology 647 Rabbit anti-Human CD1c
This gene encodes a member of the CD1 family of transmembrane glycoproteins which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells The human genome contains five CD1 family genes organized in a cluster on chromosome 1 The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail Alternatively spliced transcript variants of this gene have been observed but their full-length nature is not known
ABclonal Technology 488 Rabbit anti-Human CD1c
This gene encodes a member of the CD1 family of transmembrane glycoproteins which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells The human genome contains five CD1 family genes organized in a cluster on chromosome 1 The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands The protein encoded by this gene is broadly distributed throughout the endocytic system via a tyrosine-based motif in the cytoplasmic tail Alternatively spliced transcript variants of this gene have been observed but their full-length nature is not known
ABclonal Technology 647 Rabbit anti-Human CD47
This gene encodes a membrane protein which is involved in the increase in intracellular calcium concentration that occurs upon cell adhesion to extracellular matrix The encoded protein is also a receptor for the C-terminal cell binding domain of thrombospondin and it may play a role in membrane transport and signal transduction This gene has broad tissue distribution and is reduced in expression on Rh erythrocytes Alternatively spliced transcript variants have been found for this gene
ABclonal Technology FITC Rabbit anti-Mouse CD32
CD32 (Fcgr2) is a 40 kD transmembrane glycoprotein member of the immunoglobulin superfamily The extracellular region of CD32 consists of two Ig C-type domains that binds the Fc region from monomeric IgG with low affinity but binds immune complexes efficiently CD32 can mediate phagocytosis of immune complexes and modulate cell activation CD32 is expressed by Macrophages neutrophils mast cells and B cells
ABclonal Technology 488 Rabbit anti-Human CD34
Enables sulfate binding activity Acts upstream of or within leukocyte migration Located in cytoplasm external side of plasma membrane and extracellular region Is expressed in several structures including alimentary system cardiovascular system extraembryonic component genitourinary system and skin Orthologous to human CD34 (CD34 molecule)
ABclonal Technology 488 Rabbit anti-Human CD34
Enables sulfate binding activity Acts upstream of or within leukocyte migration Located in cytoplasm external side of plasma membrane and extracellular region Is expressed in several structures including alimentary system cardiovascular system extraembryonic component genitourinary system and skin Orthologous to human CD34 (CD34 molecule)
ABclonal Technology PCSK9 Rabbit mAb
This gene encodes a member of the subtilisin-like proprotein convertase family which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway The encoded protein undergoes an autocatalytic processing event with its prosegment in the ER and is constitutively secreted as an inactive protease into the extracellular matrix and trans-Golgi network It is expressed in liver intestine and kidney tissues and escorts specific receptors for lysosomal degradation It plays a role in cholesterol and fatty acid metabolism Mutations in this gene have been associated with autosomal dominant familial hypercholesterolemia Alternative splicing results in multiple transcript variants
ABclonal Technology ABflo 594 Rabbit anti-Rat CD31
Enables protein phosphatase binding activity Involved in several processes including cellular response to interferon-gamma negative regulation of GTPase activity and negative regulation of actin filament polymerization Located in cell surface and ruffle Used to study pulmonary hypertension Biomarker of bacterial pneumonia orchitis and osteoarthritis Human ortholog(s) of this gene implicated in coronary artery disease (multiple) lung non-small cell carcinoma neuroblastoma and psoriatic arthritis Orthologous to human PECAM1 (platelet and endothelial cell adhesion molecule 1)
ABclonal Technology ABflo 594 Rabbit anti-Rat CD31
Enables protein phosphatase binding activity Involved in several processes including cellular response to interferon-gamma negative regulation of GTPase activity and negative regulation of actin filament polymerization Located in cell surface and ruffle Used to study pulmonary hypertension Biomarker of bacterial pneumonia orchitis and osteoarthritis Human ortholog(s) of this gene implicated in coronary artery disease (multiple) lung non-small cell carcinoma neuroblastoma and psoriatic arthritis Orthologous to human PECAM1 (platelet and endothelial cell adhesion molecule 1)
ABclonal Technology PE Rabbit anti-Mouse CD23 mAb
Predicted to enable carbohydrate binding activity Acts upstream of or within positive regulation of humoral immune response mediated by circulating immunoglobulin Located in external side of plasma membrane Orthologous to human FCER2 (Fc fragment of IgE receptor II)
ABclonal Technology 594 Rabbit anti-Human CD99
The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration T-cell adhesion ganglioside GM1 and transmembrane protein transport and T-cell death by a caspase-independent pathway In addition the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation There is a related pseudogene located immediately adjacent to this locus
ABclonal Technology 610 Rabbit anti-Human CD45
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth differentiation mitosis and oncogenic transformation This PTP contains an extracellular domain a single transmembrane segment and two tandem intracytoplasmic catalytic domains and thus is classified as a receptor type PTP This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling It functions through either direct interaction with components of the antigen receptor complexes or by activating various Src family kinases required for the antigen receptor signaling This PTP also suppresses JAK kinases and thus functions as a regulator of cytokine receptor signaling Alternatively spliced transcripts variants of this gene which encode distinct isoforms have been reported
ABclonal Technology 647 Rabbit anti-Human ROR1
This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia Alternative splicing results in multiple transcript variants encoding different isoforms
ABclonal Technology 488 Rabbit anti-Human CD75
This gene encodes a member of glycosyltransferase family 29 The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates The protein which is normally found in the Golgi but can be proteolytically processed to a soluble form is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6 CD75 and CD76 This gene has been incorrectly referred to as CD75 Alternative splicing results in multiple transcript variants
ABclonal Technology 488 Rabbit anti-Human CD75
This gene encodes a member of glycosyltransferase family 29 The encoded protein is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to galactose-containing substrates The protein which is normally found in the Golgi but can be proteolytically processed to a soluble form is involved in the generation of the cell-surface carbohydrate determinants and differentiation antigens HB-6 CD75 and CD76 This gene has been incorrectly referred to as CD75 Alternative splicing results in multiple transcript variants